Study of the Corrective Mechanisms of Total Polyphenols Isolated from Plantago major L. on Hepatocellular Structural Changes under Experimental Diabetes Mellitus Conditions

Abstract

Research purpose P. major l. from the plant separate received polyphenols of the sum in rats alloxane using called experiential sugary diabetes in dynamics liver of hepatocytes morphological to the structure effect from assessment consists of Experimental alloxan sugary diabetes male rats belly to the void alloxan one 0.4 ml of citrate at a dose of 150 mg/kg once in the clipboard input the way with we called Group I animals control the group organize did , group II to animals every day mouth through polyphenols in the amount of 50 mg/kg , group III to animals and - at a dose of 100 mg/kg entered . 8 rats intact the group organize did Ether narcosis effect under animals decapitation the way with alloxane diabetes it was slaughtered on the 21st day of its development . P. major l. polyphenols amount when used , liver in the tissue hemocirculator disorders and some of hepatocytes destructive changes with in small quantities liver parenchyma damage furnaces observed . Dystrophy mixed character ( protein , fat dystrophy ), necrotic changes more of fragments central in parts to be in the portal tracts of infiltration lack of experiential alloxane in diabetes P. major l. polyphenols of the amount healer feature from existence proof gives